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. 2014 Aug 8;15(1):267. doi: 10.1186/1471-2105-15-267

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© Bisgin et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Overview of the study. A) Integrating side-effects and indications to complete phenome; B) Determining the number of topics by using information loss; C) Hiding known indications one by one to see the recovery potential for decision criteria; D) Developing the decision criteria considering recovered indications with significance; E-F) LDA is applied to the drug-phenome matrix. Observing the decision criteria, real indications were recovered for drugs without indication information and new indications suggested for remaining drugs.