Table 2.
Accuracy of HPV test, cytology and the combination of both tests for CIN2+ prediction
| HPV | CYTOLOGY | HPV + CYTOLOGY | ||
|---|---|---|---|---|
| SENSITIVITY (95% CI) | Uncorrecteda | 94.4 (92.8-96.1) | 44.4 (39.2-49.7) | 94.4 (92.8-96.1) |
| Correctedb | 90.5 (88.8-92.2) | 38.2 (33.9-42.6) | 90.5 (88.8-92.2) | |
| SPECIFICITY (95% CI) | Uncorrecteda | 88.8 (86.4-91.2) | 96.4 (95.1-97.7) | 87.2 (84.6-89.7) |
| Correctedb | 93.0 (91.5-94.5) | 97.8 (97.0-98.7) | 91.9 (90.3-93.5) | |
| PPV (95% CI) | Uncorrecteda | 16.8 (10.4-23.3) | 22.9 (16.6-29.1) | 15.0 (21.6-8.5) |
| Correctedb | 16.1 (11.0-21.1) | 20.9 (15.9-25.8) | 14.2 (9.1-19.3) | |
| NPV (95% CI) | Uncorrecteda | 99.8 (99.6-100.1) | 98.6 (97.8-99.5) | 99.8 (99.6-100) |
| Correctedb | 99.8 (99.6-100.1) | 99.1 (98.5-99.6) | 99.8 (99.6-100) | |
aEstimates based only on data from women who were screened.
bEstimates corrected for bias due to loss of follow-up.
CIN2+: cervical intraepithelial neoplasia grade 2 or worse, hrHPV: HPV testing for high-risk types, PPV: positive predicted value, NPV: negative predicted value, 95% CI: 95% Confidence Interval.
HPV detection was performed with Hybrid Capture 2 test (HC2; Qiagen, Gaithersburg, MD, USA).