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Loss of Gata3 alters the antral shape and the flexure of the pyloric region. Whole mount photomicrographs of pylorus from WT (A) and Gata3lacZ/lacZ (G3KO) (B) embryos at E18.5. Loss of Gata3 results in attenuation of the pyloric constriction (10), subtle but reproducible alteration of antral shape, and at the pylorus, the angle of flexure between the stomach and duodenum is altered. Orientation is as follows: stomach is left, and dorsal is up.
