Fig. 4.

Overexpression of HDAC4 in c-kit⁺ CSCs attenuated cardiac functional improvement in MI hearts engrafted with adenoviral HDAC4-infected c-kit⁺ CSCs (A). LV functional parameters include LVDP, LV dP/dt_max, LV dP/dt_min, RPP, and HR. The values represent means ± SE. *P < 0.05 vs. sham and control adenoviral GFP-infected c-kit⁺ CSCs (n = 5 per group). Echocardiographic analyses of cardiac function after 2 wk of MI (B). Values represent means ± SE. **P < 0.01 vs. sham and control adenoviral GFP-infected c-kit⁺ CSCs (n = 5 per group).