Fig. 4.

Intravesical administration of a TRPV4 agonist does not change bladder function in rats exposed to 7 d of RVS. Representative cystometrogram recordings of effects of a TRPV4 agonist (GSK1016790A) in a rat that has been exposed to 7 d of RVS using continuous intravesical infusion of saline. Pre-GSK1016790A (A) and post-GSK1016790A (B) bladder function traces in an RVS treated are shown. TRPV4 receptor activation with intravesical infusion of GSK1016790A (3 μM) did not change bladder capacity or void volume compared with pretreatment conditions. Infused volume (ml, top), bladder pressure (kPa, middle), and void volume (ml, bottom) are shown in A and B, which were recorded from the same rat.