Fig. 6.

Model showing systems hypothesized to be potentially contributing to how exposing mice to 21 days of chronic hypoxia attenuates the acute pulmonary arterial hypoxic pulmonary vasoconstriction (HPV) response through increasing hydrogen peroxide. The beneficial effects of 21 days of ALA treatment functioning through attenuating pulmonary hypertension and the generation of vasodilator levels of extracellular hydrogen peroxide potentially through its attenuation of the generation of superoxide are shown. PKG, cGMP protein kinase; PpIX, protoporphyrin IX.