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Dose-dependent effects of methacholine on Rrs (A) and Crs (B) in 3-wk-old mice exposed to neonatal hyperoxia (40% or 70% oxygen, from birth to P7) or normoxia (Ctrl). Slope of the responses of Rrs and Crs to methacholine in 40%-exposed mice were significantly different from Ctrl and 70% oxygen-exposed mice. *Slope is significantly difference from control, P < 0.001.
