| A |
Eyes with small discrete tumors away from critical structures. All tumors are ≤3 mm, confined to the retina, and located at least 3 mm from the foveola and 1.5 mm from the optic nerve. No vitreous or subretinal seeding is allowed. |
Retinoblastoma tumor ≤3 mm (in basal dimension or thickness) |
| B |
Eyes with no vitreous or subretinal seeding and retinal tumors of any size or location. Retinal tumors may be of any size or location not in group A. A small cuff of subretinal fluid extending ≤5 mm from base of the tumor is allowed. |
Retinoblastoma tumor >3 mm or macular location (≤3 mm from foveola)Juxtapapillary location (≤1.5 mm to disc)Subretinal fluid ≤3 mm from margin |
| C |
Eyes with only focal vitreous or subretinal seeding and discrete tumors of any size or location. Any seeding must be local, fine and limited so as to be theoretically treatable with a radioactive plaque. Retinal tumors are discrete and of any size and location. Up to one quadrant subretinal fluid may be present. |
Retinoblastoma tumors with subretinal seeds ≤3 mm from tumorVitreous seeds ≤3 mm from tumorBoth subretinal and vitreous seeds ≤3 mm from tumor |
| D |
Eyes with diffuse vitreous or subretinal seeding and/or massive non discrete endophytic or exophytic disease. Seeding more extensive than Group C. Massive and/or diffuse intraocular disseminated disease may consist of fine or “greasy” vitreous seeding or avascular masses. Subretinal seeding may be plaque-like. Includes exophytic disease and >1 quadrant retinal detachment. |
Retinoblastoma tumors with subretinal seeds >3 mm from tumorVitreous seeds >3 mm from tumorBoth subretinal and vitreous seeds >3 mm from tumor |
| E |
Eyes that have been destroyed anatomically or functionally by the tumor. Eyes with one or more of the following. Irreversible neovascular glaucoma, massive intraocular hemorrhage, aseptic orbital cellulitis, tumor anterior to anterior vitreous face, tumor touching lens, diffuse infiltrating retinoblastoma, phthisis or pre-phthisis |
Extensive retinoblastoma occupying >50% of the globe or neovascular glaucomaOpaque media from hemorrhage in anterior chamber, vitreous or subretinal spaceInvasion of postlaminar optic nerve, choroid (>2 mm), sclera, orbit, anterior chamber |
