Table 3.
Comparison of the metabolism velocities for angiotensins and other peptides. Velocity is an approximation of Vmax, as reactions are carried out in the presence of excess peptide substrate. NC = not cleaved within 24 hours of digestion.
| Peptide | Amino Acid Sequence | Velocity (nmol/min/mg) |
|---|---|---|
| Ang I | DRVYIHPFHL | 2.0 |
| Ang II | DRVYIHPF | 4.9 |
| Ang-(1–7) | DRVYIHP | 54 |
| Ang-(1–6) | DRVYIH | 27 |
| Ang-(1–5) | DRVYI | 2.1 |
| Neurotensin | ELYENLPRRPYIL | NC |
| Bradykinin-(1–9) | RPPRFSPFR | NC |
| Bradykinin-(1–7) | RPPRFSP | NC |
| Bradykinin-(1–5) | RPPRF | NC |
| Apelin 13 | KFRRQRPRLSHKG | NC |