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. 2014 May 13;25(8):759–771. doi: 10.1089/hum.2012.216

FIG. 5.

FIG. 5.

Biodistribution of retroviral replicating vector (RRV) in immune-competent mice engrafted with tumor infected with vector carrying the 142-3pT sequences. (A) Tumor growth in mice engrafted with tumor infected with RRV carrying the 142-3pT sequences. (B) Scatter plot of the vector copy number of proviral DNA in tumor infected with pAC3-GFP, pAC3-GFP-142-3pT, or pAC3-GFP-142-3pT4X vector on approximately day 20 after tumor engraftment. Each symbol represents one mouse. (C) Scatter plot of anti-MLV immune response measured on approximately day 20 after tumor engraftment. Control group consisted of mice engrafted with subcutaneous tumor without RRV infection. Mean values and standard deviations are shown. One-way analysis of variance (ANOVA) was performed for statistical analysis, and values from samples scored as lower limit of quantification (LLOQ) (fewer than 250 copies/μg) were included in the analysis. *Significant difference (p<0.05). OD, optical density; ns, not significant.