FIG. 5.
T cells expressing ErbB2369–377-specific TCR7 delay tumor growth in vivo. T cells expressing ErbB2369–377-specific TCR7 delay tumor growth in vivo. Retrovirally transduced ErbB2 TCR7 CD8+ T cells and the breast cancer cell line MDA231 were co-injected subcutaneously into the flank of NSG mice on day 0. MART1-specific F5 TCR-transduced T cells co-injected with MDA231 were used as controls. (A) Tumor growth was determined by caliper measurement over time. Results are expressed as mean tumor volume (mm3±SEM) with n=5 for all groups. Statistical significance of p<0.05 is reported as *p=0.0495, **p=0.0075, and ***p=0.0029. After 35 days, tumors were resected, photographed (B), and measured for tumor weight (C). NSG, NOD/SCID/γ-chain−/−.