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. 2014 Apr 1;20(15-16):2115–2126. doi: 10.1089/ten.tea.2013.0455

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Copyright 2014, Mary Ann Liebert, Inc.

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FIG. 4. — Real-time PCR analyses of various vSMC-secreted inflammatory markers when cultured on the different substrata. ANFS, for the most part, decreased the gene expression of inflammatory cytokines for both the soft and stiff substrata (p<0.05) and thus made ANFS more biomimetic. Notably, the levels of monocyte chemoattractant protein-1 (MCP-1) expression increased around twofold on stiff ANFS relative to soft ANFS. Statistically significant difference between nanopatterned and unpatterned substrata (p<0.05) for the same substratum stiffness is indicated with an asterisk. For all other substrata-type combinations, the identical signage indicates statistically significant difference for that pair.