Table 3. Aqueous Solubility of Amine-Containing Bioactive Compounds^a.

^aSolubility was measured in H₂O after an incubation period of 24 h at 30 °C and rounded to 2 significant digits. See SI for full experimental details including standard deviations.

^bCalculated with Instant JChem 6.3, 2014, ChemAxon (http://www.chemaxon.com).

^cn = 1 (literature value for HCl salt was 1,000 μg/mL).²⁸

^dn = 3.

^en = 1 (literature value for HCl salt is 100 μg/mL).²⁸

^fn = 2.