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. 2014 Jun 24;5(8):857–862. doi: 10.1021/ml500117c

Figure 4.

Figure 4

Dose-dependent effects of 3a (cebranopadol) hemicitrate on heat nociception (tail-flick and hot plate in STZ control animals), on thermal hyperalgesia (hot plate in STZ diabetic animals), and on motor coordination (rota rod) after i.v. administration in mice. #, Relative effect refers to percentage of maximum possible effect (% MPE) for tail-flick and STZ models, or relative decrease in performance time on the rotating rod (rota rod). Error bars indicate SEM (n = 10). *, p < 0.05 versus vehicle control.