Dose-dependent effects of 3a (cebranopadol)
hemicitrate
on heat nociception (tail-flick and hot plate in STZ control animals),
on thermal hyperalgesia (hot plate in STZ diabetic animals), and on
motor coordination (rota rod) after i.v. administration in mice. #, Relative effect refers to percentage of maximum possible
effect (% MPE) for tail-flick and STZ models, or relative decrease
in performance time on the rotating rod (rota rod). Error bars indicate
SEM (n = 10). *, p < 0.05 versus
vehicle control.