Table 5. Pharmacokinetics in Rat.

		IV			PO
compd	cLogP	Cl (L/h/kg)	Vss (L/kg)	T1/2 (h)	Cmax (ng/mL)	AUClast (ng/mL·h)	T1/2 (h)	F (%)
4a	2.24	3.9	5.42	2.4	175	880	2.8	35
9b	1.90	3.67	2.78	0.8	86	249	1.5	12
10a	2.40	5.44	5.89	1.2	198	896	3.3	48
18a	1.68	5.04	4.55	1.1	291	541	1.6	28
27c	2.48	2.40	6.17	1.83	1250	3980	2.4	97
29d	3.26	2.16	12.2	4.72	256	1610	4.4	89
30d	0.2	1.65	1.02	2.48	3.52	19.5	1.9	<1
31a	1.11	4.39	4.22	0.8	103	209	3.7	9

^aDose: po at 10 mg/kg; iv at 5 mg/kg (n = 3).

^bDose: po at 8 mg/kg; iv at 4 mg/kg (n = 3).

^cDose: po at 10 mg/kg; iv at 10 mg/kg (n = 3).

^dDose: po at 4 mg/kg; iv at 2 mg/kg (n = 3).