Table 4. Pharmacokinetic Parameters Following 20 mg/kg oral and 5 mg/kg Intravenous Dosing in Mice^a.

	oral PKb parameters					intravenous PK parameters
cmpd	Cmax (μM)	Tmax (h)	AUC (μM·h)	T1/2 (h)	F (%)	Vss (L/kg)	CL (mL/min/kg)	T1/2 (h)
17	0.02	1.7	0.12	3.39	0.24	0.99	16.2	2.12
18	8.3	0.5	11.14	1.35	51.6	0.90	39.7	0.62
19	5.2	0.5	12.4	1.63	51.9	1.02	34.0	0.42
20	20.5	0.5	31.2	3.63	60	0.96	19.3	0.83

^aC_max, maximum concentration of drug in plasma; T_max, time to maximum concentration of drug in plasma; AUC, area under the curve extrapolated to infinity; V_ss, volume of distribution at steady state; CL, clearance; T_1/2, half-life; F, oral bioavailability;

^bFormulation used for oral and intravenous dosing is PEG300/D5W (3:1, V/V).