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In vitro monitoring of histone hyperacetylation and metabolic stability of largazole and largazole disulfide analogues. Time-course monitoring of histone hyperacetylation in HCT116 cells: (A) 8 and (B) 24 h. (C) Cellular stability of prodrugs in HCT116 cell lysates. (D) Amount of generated largazole thiol from each prodrug (measured as NEM adduct).
