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. Author manuscript; available in PMC: 2014 Aug 19.
Published in final edited form as: J Neurochem. 2007 Nov 5;105(1):78–90. doi: 10.1111/j.1471-4159.2007.05108.x

Fig. 4.

Fig. 4

(a) Representative coronal section of TH immunohistochemistry in control and MPTP-treated baboon brains at the level of the caudate and putamen. The intensity of gray scale represents the level of TH immunostaining. (b) TH optical density in the subregions of caudate, putamen and nucleus accumbens in control (n = 3) and MPTP animals (n = 5). Each value represents the mean ± SEM. (*p < 0.05). (c) Representative coronal section of TH immunohistochemistry in control and MPTP baboon brains at the level of the substantia nigra. (Scale bar = 1000 μm in upper row and 100 μm in lower row). There is a significant loss of TH immunostaining in the substantia nigra pars compacta (SNc) and pars reticulata (SNr) in the MPTP-treated animals compared to control (upper row). Higher magnification images of TH positive neurons in the SNc of control and MPTP-treated animals (lower row). (d) Analysis of TH positive cell numbers in the SNc in control (n = 3) and MPTP-treated animals (n = 3). Each value represents the mean ± SEM (*p < 0.05). (e) Dopamine and metabolite concentrations in the caudate and putamen of control and MPTP-treated animals. Values are mean ± SEM of controls (n = 3) and MPTP animals (n = 5) (*p < 0.01).