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. Author manuscript; available in PMC: 2014 Aug 19.
Published in final edited form as: J Neurochem. 2007 Nov 5;105(1):78–90. doi: 10.1111/j.1471-4159.2007.05108.x

Fig. 5.

Fig. 5

Glial fibrillary acidic protein (GFAP) immunohistochemistry for astrocytes and LN3 immunohistochemistry for microglia in baboon caudate and putamen (see sketch) of control and MPTP-treated animals. (Scale bar = 100 μm). There are morphological changes in astrocytes from a resting state (control) to the activated state (MPTP) with an increase of GFAP immunostaining per cell (hypertrophy) and the total number of GFAP positive cells in subregions of the caudate and putamen. There are also morphological changes of microglia from a resting state with small cell bodies and highly ramified processes (control) to activated microglia with ‘bushy’ appearing cells as well as round phagocytotic cells (but only in some areas of the putamen from MPTP animals). We observed no microglial staining in the caudate of MPTP-treated animals.