Transcriptional control of effector and memory CD8+ T cell differentiation

. Author manuscript; available in PMC: 2014 Aug 19.

Published in final edited form as: Nat Rev Immunol. 2012 Oct 19;12(11):749–761. doi: 10.1038/nri3307

Cell type	Phenotype	Location	Functional properties
T_CM cell	CD62L^hiCCR7^hi	Lymph nodes, spleen, blood	↑ Proliferative potential ↑IL-2 production ↑ Migration ↓Effector functions and cytotoxicity
T_EM cell	CD62L^lowCCR7^low	Spleen, blood, liver	↓- Proliferative potential ↓IL-2 production ↑ Migration ↑Effector functions and cytotoxicity
T_RM cell	CD103^hiCD69^hiCD62L^lowCD27^low; expression of tissue-specific chemokine receptors and integrins^*	Skin, lung, gut, brain	↓- Proliferative potential ↓IL-2 production ↓-Migration ↑Effector functions and cytotoxicity

Following localized infection, tissue-specific chemokine and adhesion molecule signals direct the migration of effector and memory T cells to the sites of infection. For example, CC-chemokine receptor 9 (CCR9) and integrin α4β7 are required for homing to the gut, whereas CCR4, CCR10 and cutaneous lymphocyte antigen (CLA) are required for homing to the skin.