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. 2014 Aug 19;2:27. doi: 10.3389/fbioe.2014.00027

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Copyright © 2014 Korsunsky, McGovern, LaGatta, Olde Loohuis, Grosso-Applewhite, Griffeth and Mishra.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic view of signal transduction in the pancreatic cancer model. Blue nodes represent tumor-suppressor proteins, red nodes represent oncoproteins/lipids. Arrow represents protein activation, circle-headed arrow represents deactivation. The acronyms in each rectangular node stand for signal transduction proteins. The rounded rectangular nodes on the top of the figure stand for ligands that activate the pathways. Finally, the rounded nodes at the bottom stand for a cell behavior activated by the connected effector proteins. Figure adapted from Gong et al. (2011c).