Table 7.
Summary of developmental concerns in sample of 85 cases detected by newborn screening
| Disorder (n) | Developmental Concerns (n and %) | Speech (n and %) | Motor (n and %) | DQ (mean ± SD) | IQ (mean ± SD) | Cognitive Delay (n and %)a |
|---|---|---|---|---|---|---|
| MCADD (27) | 18 (67%) | 13 (48%) | 7 (26%) | 105 ± 25 | 109 ± 11 | 2/17 (12%) |
| VLCADD (14) | 8 (57%) | 4 (29%) | 7 (50%) | 99 ± 21 | 115 ± 4 | 1/11 (9%) |
| LCHADD (2) | 2 (100%) | 2 (100%) | 1 (50%) | – | 75 | 1/1 (100%) |
| Primary Carnitine Deficiency (7) | 2 (29%) | 1 (14%) | 2 (29%) | 120 | 105, 113 | 0/3 (0%) |
| SCADD (35) | 16(46%) | 6 (17%) | 7 (20%) | 106 ± 12 | 113 ± 28 | 1/14 (7%) |
| TOTAL (85) | 46 (54%) | 26 (31%) | 24 (29%) | 105 ± 19 | 110 ± 16 | 5/46 (11%) |
a
Cognitive delay defined as DQ or IQ < 85 (1 standard deviation below the normative mean). Percents are based on total number of cases receiving developmental or intelligence testing.