Table 5.
GMCSF-PLP exhibited inhibitory activity when included in a CFA emulsion
| Included in CFA emulsion a | Incidence of EAE | Mean cumulative score | Median cumulative score | Mean maximal score | Median maximal score |
|---|---|---|---|---|---|
| GMCSF-PLP + PLP139-151 | 5 of 8 | 0.5 ± 1.4 | 0.0 | 0.1 ± 0.4 | 0.0 |
| PLP139-151 | 8 of 8 | 36.8 ± 27.0 | 41.8 | 2.6 ± 1.7 | 3.5 |
a
SJL mice were immunized on day 0 with 131 nmole (200 μg) of PLP139-151 in CFA or with a mix of 131 nmole of PLP139-151 and 2 nmole of GMCSF-PLP in the same CFA emulsion. Mice were scored daily through the end of the experiment on day 69. Shown are the data analyses for days 42-69; cumulative scores, p = 0.003; maximal scores, p = 0.002.