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Aspirin resistance in a cohort of 93 healthy subjects. Aggregation responses are shown to (A) arachidonic acid (AA, 1.6mmol l−1) and (B) ADP 30 μmol l−1 in platelet-rich plasma. Also shown are urinary 11-dehydrothromboxane B2 (11-dehydroTXB2) (C). Visits 1 and 2 represent values 1 week apart. Visit 3 represents values after subjects were treated with 300 mg aspirin daily for 28 days. ***P < 0.001 as compared with both visit 1 and visit 2
