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. Author manuscript; available in PMC: 2014 Aug 19.
Published in final edited form as: J Healthc Eng. 2012 Dec;3(4):503–534. doi: 10.1260/2040-2295.3.4.503

Figure 1.

Figure 1

Mass spectrometry preparations for potential cancer diagnostics. A) In matrix assisted laser desorption/ionization (MALDI), a sample is mixed with a matrix solution and then spotted onto a surface to dry. B) In surface enhanced laser desorption/ionization (SELDI), an affinity reagent is bound to the surface. The sample is exposed to the surface and then unbound portions of the sample are washed away. C) In MALDI-imaging mass spectrometry (MALDI-IMS), a tissue sample is mounted on a surface. A matrix solution is added to the sample and mass spectra are taken from defined points of the tissue to provide spatial ion concentration data.