Table 1.

Comparison between Automated and Manual Methods

	Automated Method				ISD (pu)	Manual Method				ISD (pu)
	Mean MTR S1 (pu)	Mean MTR S2 (pu)	ICC	CV (%)		Mean MTR S1 (pu)	Mean MTR S2 (pu)	ICC	CV (%)
Gray Matter Regions
Left amyg	41.94	41.41	0.92	2.64	1.10	42.21	42.02	0.87	3.40	1.43
Right amyg	42.06	41.63	0.90	2.29	0.96	42.04	42.67	0.85	2.83	1.20
Left cau	40.31	39.65	0.92	2.18	0.87	40.80	39.87	0.93	2.21	0.89
Right cau	39.82	39.05	0.93	2.13	0.84	40.12	39.99	0.94	2.10	0.84
Left put	41.22	40.82	0.93	2.05	0.84	41.75	41.86	0.86	2.94	1.23
Right put	41.02	40.71	0.96	1.52	0.62	42.03	41.90	0.95	1.57	0.66
Left thal	45.61	44.94	0.95	1.50	0.68	45.47	45.51	0.93	1.80	0.82
Right thal	45.97	45.09	0.93	1.63	0.74	45.60	46.25	0.96	1.39	0.64
Left hipp	39.88	40.10	0.92	2.33	0.93	41.00	41.93	0.76	4.03	1.67
Right hipp	40.01	39.92	0.94	1.83	0.73	41.05	40.68	0.84	3.01	1.23
White Matter Regions
Left WM	49.47	49.23	0.84	1.56	0.77	49.28	49.23	0.88	1.44	0.71
Right WM	49.93	49.54	0.89	1.29	0.64	49.30	48.82	0.85	1.83	0.9
Genu	50.59	49.97	0.77	1.83	0.92	52.21	52.13	0.89	1.30	0.68
Splen	51.31	50.93	0.88	1.47	0.75	52.62	51.81	0.80	2.13	1.11

S1 and S2- Time-point 1 and Time-point 2, ISD-Instrumental Standard Deviation, CV-Coefficient of Variation, ICC- Intra Class Correlation Coefficient, L-Left, R-Right, Amyg-Amygdala, Caud-Caudate, Puta-Putamen, Thal-Thalamus, Hipp-Hippocampus, WM-White Matter, SN-Substantia Nigra, Genu-Genu, Splen-Splenium.