Table 1.
Effect of vinblastine (VBL) treatment on body weight and mortality rate of different groups of rats
| Body weight (g) | Mortality rate | |||||
|---|---|---|---|---|---|---|
| Group | aPND 23 | PND 30 | PND 37 | PND 45 | PND 52 | |
| bSaline M | 48.2±4.01 | 80.7±4.2 | 115.5±6.1 | 150.1±5.8 | 167.8±8.1 | 1 |
| cSaline F | 45.8±3.3 | 71.5±3.3 | 105.6±4.9 | 123.7±7.6 | 129±8.3 | 0 |
| d VBL M | 46.6±2.7 | 74.1±7.1 | 75.04±6.3** | 100.5±6.2** | 110.2±6.5*** | 3 |
| e VBL F | 48.1±5.3 | 70.5±6.6 | 96.8±8.1 | 97.9±4.5** | 105.9±5.1** | 2 |
No differences were observed in weight between saline and VBL groups on the 1st day of experimental procedure, while long-term exposure to VBL 0.2 mg/kg (the 2nd, 3rd, and 4th weeks) significantly decreased body weight in the male VBL group and in the 3rd and 4th weeks in female VBL rats. **, *** P< 0.01, P< 0.001, indicate statistically significant differences between male and female VBL treated rats compared with saline groups, respectively, (n=at least 12 rats in each group). a: Postnatal Day, b: Saline Male c: Saline Female, d: VBL Male and e: VBL Female