Table 1.

Timetable for drug administrations in each study group

	Group 6	Group 5	Group 4	Group 3	Group 2	Group 1
Week 1	Panto/Veh BDE	Panto/Veh	Panto/Veh	Panto/Veh	Panto/Veh	Panto/Veh App insertion
Week 2	Panto/Veh BDE	Panto/Veh	Panto/Veh	Panto/Veh	Panto/Veh App insertion	Panto/Veh
Week 3	Panto/Veh BDE	Panto/Veh	Panto/Veh	Panto/Veh App insertion	Panto/Veh	OTM measurement
Week 4	Panto/Veh BDE	Panto/Veh	Panto/Veh App insertion	Panto/Veh	OTM measurement
Week 5	Panto/Veh BDE	Panto/Veh App insertion	Panto/Veh	OTM measurement
Week 6	Panto/Veh BDE App insertion	Panto/Veh	OTM measurement
Week 7	Panto/Veh	OTM measurement
End	OTM measurement

OTM: Orthodontic tooth movement; App: Appliance; Panto/Veh: Pantoprazole/vehichle administration, BDE: Bone densitometry evaluation