Fig. 4.

a Mean K^trans changes of groups 1–4 during 3 days posttherapy in peripheral tumor region with the best-fitting second-order polynomial curves for the four groups. b Maximum K^trans increases (MaxK) and days of maximum K^trans increases (DMaxK) retrieved from the second-order polynomial curves fitting to the K^trans changes in the peripheral tumor region during 3 days posttherapy of groups 2–4; different Greek letters present statistical differences among the groups (lowercase letters for MaxK, uppercase letters for DMaxK).