Figure 5. Validation of the model predictions using deep sequence data.
Comparison of the model-predicted and actual (deep sequence) resistance frequency. (A) Predicted resistance frequency for samples with undetectable resistance by deep sequencing. (B) Predicted versus actual resistance frequency for samples with measurable resistance by deep sequencing. The p-value of the prediction is <10−4 as determined by Monte Carlo simulation. (C) The differences between the modeled and actual resistance frequency are depicted in the histogram (counts indicated above each bar), with a median % difference of -3.3e-5 and a mean % difference of 1.3.