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. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: Nature. 2014 May 28;511(7507):90–93. doi: 10.1038/nature13283

Figure 3. Targeting Gli1 activity.

Figure 3

A. FRII cell growth +/− GDC-0449 (GDC) and ribavirin or Ara-C. B. The ribavirin-eIF4E complex is measured as a function of Gli1 status using 3H-ribavirin and eIF4E immunoprecipitation relative to IgG controls: FaDu-Gli1 cells, siGli1, GDC-0449 treatment. See Extended Data Figure 6 for immunoprecipitation controls. C. Methyl-cellulose colony growth assays in specimens from M4/M5 AML patients or healthy volunteers (bone marrow). All panels: Mean +/− SD (error bars). Results are representative of at least three independent experiments in triplicate (A–D) or at least two (E) in replicates of 5. p-value <0.01 **, and p-value<0.001 *** (Student’s t-test).