Skip to main content
. Author manuscript; available in PMC: 2015 Jan 3.
Published in final edited form as: Nature. 2014 May 28;511(7507):90–93. doi: 10.1038/nature13283

Figure 4. Link between Gli1, UGT1A and drug glucuronidation.

Figure 4

A–C. Westerns as a function of Gli1. HSP90 provides a loading control. D–I. MS/MS extracted ion chromatographs are shown. Rib-Glu Ribavirin Glucuronide; RDP* (ribavirin diphosphate minus H2O). Fragmentation of Rib-Glu peak confirms its identity (Extended Data Figure 7). J. Ribavirin, the best-supported glucuronidation site indicated by red arrow. K. Glucuronic acid L. RDP M. 3H ribavirin-eIF4E-GST complexes competed by equimolar amounts of compounds. 3H ribavirin did not bind beads alone. See Extended Data Figure 7D for loading. Averages +/− SD (error bars). Experiments were carried out in triplicate, at least three independent times.