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. Author manuscript; available in PMC: 2014 Aug 19.
Published in final edited form as: Stem Cells. 2012 Feb;30(2):222–231. doi: 10.1002/stem.771

Fig. 3.

Fig. 3

Mast cell derived factors increase IL-6 production of BMSCs in vitro. A: IL-6 production of BMSCs is not effected by co-culturing them with human MCs at a 1:1 ratio. When the MCs are first degranulated (ActMC) and then co-cultured with the BMSCs, there is a significant increase in the IL-6 production (p<0.001). Adding a H1 receptor antagonist to the media significantly decreases the production of IL-6 by BMSCs. B: prostaglandin D2, another major MC mediator also induces BMSC derived IL-6 secretion. Since PGD2 was dissolved in ethanol, the individual controls (C1-3) contain the same EtOH concentration. In 10−6 and 10−5 Molar concentrations PDG2 significantly increases the IL-6 production of BMSCs after 6 hours of treatment.