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. 2014 Aug 19;9(8):e104282. doi: 10.1371/journal.pone.0104282

Figure 6. Integrative pathways from different cross-talking pathway pairs.

Figure 6

(A) “Complement and coagulation cascades” and “Pathway in cancer_1”, “Hedgehog signaling pathway” and “Pathway in cancer_2”; (B) “Axon guidance” and “MAPK signaling pathway”. Each ellipse represents a gene in KEGG pathway or ppi network. For a given gene, the ellipse is divided into four parts (from left to right) corresponding to different molecular level with abnormal states (red) in mRNA expression, (green) DNA methylation, (yellow) copy number and blue (somatic mutation), respectively.