Table 3. Significant dose-responses of PCB 180 based on adipose tissue concentration.

Parameter			CES 5%			CES 10%
	Sex	Model	CED (µg/g lipid)	CED-L (µg/g lipid)	Ratio CED/CED-L	CED (µg/g lipid)	CED-L (µg/g lipid)	Ratio CED/CED-L	Maximum responseb (%)
Open field behavior
Percent time in inner zone, day 24	F	E4	1.55	0.525	2.95	3.17	1.07	2.96	111
Percent distance in inner zone, day 24	F	E4	4.12	1.16	3.54	8.69	2.423	3.59	53.0
Habituation, time	F	E2	1130	739	1.53	2320	1518	1.53	−40.1
Habituation, distance	F	E2	1340	865	1.55	2740	1777	1.54	−35.2
Hematology
Red blood cell count	M	E4	598	337	1.77	1890	NAa	NA	−12.4
Red blood cell count	F	E2	4170	3327	1.25	8560	6834	1.25	−13.0
Hematocrit	M	E4	601	247	2.43	2090	NA	NA	−11.7
Hematocrit	F	E2	5430	4178	1.30	11100	8582	1.29	−10.1
Hemoglobin	M	E4	872	227	3.84	NA	NA	NA	−8.59
Hemoglobin	F	E2	4840	3889	1.24	9930	7989	1.24	−11.3
Platelet count	M	E4	156	36.4	4.29	539	NA	NA	12.0
Red cell distribution width - SD	F	E3	8370	5756	1.45	10700	9281	1.15	11.1
Clinical chemistry
Chlolesterol	M	E4	177	91.4	1.94	365	189	1.93	81.7
Chlolesterol	F	E4	640	387	1.65	1330	813	1.64	53.8
Triglycerides	M	E4	12.5	7.26	1.72	26.2	15.2	1.73	−62.5
Total protein	M	E4	1080	575	1.88	2970	1629	1.82	14.2
Glucose	M	E2	866	632	1.37	1780	1297	1.37	−35.4
Glucose	F	E2	4450	2648	1.68	9140	5440	1.68	−12.2
Alkaline phosphatase	M	E2	2300	1393	1.65	4730	2861	1.65	−15.4
Alkaline phosphatase	F	E4	308	136	2.27	701	309	2.27	−25.7
Albumin	M	E2	6750	4696	1.44	13200	9174	1.44	5.49
Potassium	F	E2	7900	5086	1.55	16200	10450	1.55	−7.07
Total Bilirubin	F	E4	19.4	3.77	5.14	48.2	8.98	5.37	−18.2
Thyroid
Thyroid gland weight	M	E2	1030	720	1.43	2010	1407	1.43	41.9
Thyroid gland weight	F	E2	3010	1698	1.77	6190	3488	1.77	−17.6
Relative thyroid gland weight	M	E2	958	710	1.35	1870	1388	1.35	45.7
Relative thyroid gland weight	F	E2	3220	1759	1.83	6610	3614	1.83	−16.5
Serum free T4 (S-fT4)	M	E4	158	117	1.35	328	243	1.35	−67.2
Serum free T4 (S-fT4)	F	E2	821	683	1.20	1690	1402	1.21	−50.7
Serum free T3 (S-fT3)	M	E4	428	196	2.18	976	449	2.18	−25.0
Serum free T3 (S-fT3)	F	E2	2280	1496	1.52	4680	3072	1.52	−22.5
Serum TSHc	M	E4	0.29	0.04	6.50	0.58	0.09	6.50	5450
Serum TSHc	F	E2	206	126	1.63	402	246	1.63	1355
Large thyroid follicles (%)	F	E4	105	52.7	1.99	218	110	1.99	−70.9
Gonadotropins
Serum LH	M	E2	1160	648	1.79	2390	1331	1.80	−27.8
Serum FSH	M	E2	1600	1116	1.43	3290	2292	1.44	−21.1
Retinoids
Liver retinol concentration	M	E4	31.2	18.8	1.66	66.6	40.0	1.66	−44.6
Liver retinol concentration	F	E2	1000	762	1.31	2060	1565	1.32	−43.9
Liver retinyl esters concentration	M	E4	108	60.1	1.80	225	126	1.79	−63.4
Liver retinyl esters concentration	F	E2	793	670	1.18	1630	1375	1.19	−51.9
Liver all-trans RA concentration	M	E2	1920	1143	1.68	3750	2233	1.68	20.7
Liver 9c-4o-13,14-dh-RA concentration	F	E4	55.5	39.6	1.40	115	82.1	1.40	−78.2
Liver retinol amount	M	E2	1860	1111	1.67	3820	2282	1.67	−18.5
Liver retinol amount	F	E2	2840	1476	1.92	5820	3032	1.92	−18.5
Liver retinyl esters amount	M	E2	620	525	1.18	1270	1078	1.18	−45.7
Liver retinyl esters amount	F	E2	1620	1206	1.34	3300	2477	1.33	−30.1
Liver all-trans RA amount	M	E2	95.1	36.8	2.58	196	76	2.58	92.7
Liver 9c-4o-13,14-dh-RA amount	F	E4	59.6	37.4	1.59	124	77.9	1.59	−70.3
Kidney retinol concentration	M	E2	863	640	1.35	1690	1250	1.35	51.9
Kidney retinol concentration	F	E2	2060	1346	1.53	4030	2630	1.53	30.7
Kidney retinyl esters concentration	M	E4	42.2	13.6	3.10	85.2	27.5	3.10	256
Kidney all-trans RA concentration	F	E2	2930	2052	1.43	5720	4009	1.43	20.7
Kidney retinol amount	M	E2	897	638	1.41	1750	1244	1.41	49.0
Kidney retinol amount	F	E2	2240	1398	1.60	4370	2731	1.60	28.0
Kidney retinyl esters amount	M	E4	38.8	12.5	3.11	78.3	25.2	3.11	253
Kidney all-trans RA amount	F	E2	3290	2092	1.57	6430	4088	1.57	18.2
Serum retinol concentration	F	E2	2470	1521	1.62	4820	2970	1.62	25.0
Bone densitometry
Cortical area of diaphysis	M	E2	5930	3506	1.69	12200	7202	1.69	−6.19
Trabecular area of metaphysis	F	E2	6230	3714	1.68	12200	7255	1.68	9.25
Bone biomechanics
F yield	F	E2	2860	1647	1.74	5880	3384	1.74	−18.3
Organ weights
Liver weight	M	E4	42.3	19.8	2.13	88.4	41.3	2.14	65.0
Liver weight	F	E4	512	263	1.95	1090	565	1.93	43.1
Relative liver weight	M	E4	61.0	34.8	1.75	127	72.4	1.75	66.0
Relative liver weight	F	E4	552	359	1.54	1170	766	1.53	44.8
Relative thymus weight	M	E2	2230	1270	1.76	4350	2480	1.75	17.6
Ovaries weight	F	E4	201	31.7	6.34	510	79.6	6.41	17.0
Relative ovaries weight	F	E5	661	67.5	9.79	826	164	5.04	16.0
DNA damage markers						CES 100%
Liver p53	F	E4	65.2	30.0	2.18	2240	1053	2.13	141
Liver p53 Ser15	F	E5	361	124	2.91	438	411	1.07	181
Liver pChk2 Thr68	F	E5	337	98.2	3.43	382	165	2.31	185
Liver enzymesd
EROD activity	M	E4	1.41	0.850	1.66	2.82	1.71	1.65
EROD activity	F	E5	33.6	15.8	2.13	57.0	29.6	1.93
PROD activity	M	E5	3.87	2.74	1.41	5.49	4.04	1.36
PROD activity	F	E5	26.4	13.5	1.96	36.5	20.2	1.81
CYP2B1 mRNA	M	E5	1.52	0.584	2.60	2.15	0.895	2.40
CYP2B1 mRNA	F	E5	12.4	5.74	2.16	15.5	7.76	2.00
CYP3A1 mRNA	M	E4	5.88	3.63	1.62	11.8	7.26	1.63
CYP3A1 mRNA	F	E4	6.75	3.19	2.12	13.5	6.39	2.11
UGT1A1 mRNA	M	E2	175	134	1.30	342	262	1.31
UGT1A1 mRNA	F	E2	423	305	1.30	826	596	1.39
UGT1A6 mRNA	M	E4	15.6	8.99	1.74	31.3	18.0	1.74
UGT1A6 mRNA	F	E4	73.8	37.8	1.95	149	76.42	1.95

^aNot available.

^bCalculated as the percent difference between controls and high dose according to the fitted model.

^cHalf min value added to zeros.

^dEnzyme induction data from Roos et al., 2011.