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. 2014 Aug 19;9(8):e104639. doi: 10.1371/journal.pone.0104639

Table 4. Margins of exposure (MoE  =  CED-L/human median PCB 180 concentration) for different endpoints of PCB 180 toxicity and different human cohorts. MoE values exceeding the WHO default uncertainty factor of 25 are bolded.

Endpoint Gender CED-L (ng/g lipid) Human cohort
Placenta (Denmark)1 Placenta (Finland)1 Mother's milk2 General population (Finland)3 Baltic Sea fishermen4 Worst case: the most exposed fisherman5
Spontanous locomotor activity F 525 54.4 94.4 11.5 5.53 1.14 0.438
Serum triglycerids M 7260 752 1306 159 76.5 15.8 6.05
Liver retinol M 18800 1948 3381 410 198 40.9 15.7
Liver p53 F 30000 3109 5396 655 316 65.2 25
Serum chlolesterol M 91400 9472 16439 1996 963 199 76.2
Serum thyroxine M 117000 12124 21043 2555 1233 254 97.5

Human PCB 180 tissue concentration data: median, range (ng/g lipid).

1

Placenta [40] (1997–2001), Denmark: 9.65, 2.03–25.2; Finland: 5.56, 1.44–14.92.

2

Mother's milk, 58 milk pools from 18 European countries [1], [2] (2001–2002): 45.8, 6.1–337.

3

Adipose tissue, general population, Finland [96] (1997–1999): 94.9, 11.3–833.

4

Adipose tissue, Baltic Sea fishermen [45] (1997–1999): 460, 190–1200.

5

Adipose tissue, Baltic Sea fisherman with highest exposure [45] (1997–1999): 120.