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. 2014 Aug 19;9(8):e104878. doi: 10.1371/journal.pone.0104878

Figure 4. Superimposition of A. aegypti ‘active’ PTP model structures with PTP1B as the reference.

Figure 4

(A) The classical PTP-domain as seen in PTP1B (PDB ID: 2AZR). The ten motifs defining the conserved PTP domain are highlighted (B) Superimposition of the active PTP-domains of Aedes agypti onto the structure of PTP1B (C) Sequence conservation defining the conserved motifs of the PTP domain. Four motifs viz., M1, M8, M9 and M10 harbour the active site residues of the PTP domain. The sequence of these motifs as seen in the Aedes aypti PTP domains are mentioned in Table 1. (D) Active site of the PTP-domain as seen in PTP1B.