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. Author manuscript; available in PMC: 2014 Aug 19.
Published in final edited form as: Org Lett. 2012 Apr 2;14(8):2026–2029. doi: 10.1021/ol300534j

Figure 2.

Figure 2

Ni-catalyzed coupling of azetidinones and alkynes. Method A (for 1b–ag except 1d): 5 mol % Ni (COD)2, 10 mol % PPh3, toluene, 60 °C, azetidinon (1 equiv, 0.2 M), alkyne (1.5 equiv). Method B (for 1d and 1h–1o): 5 mol % Ni (COD)2, 10 mol % PPh3 toluene, 100 °C, azetidinone (1 equiv, 0.2M), alkyne (3.0 equiv and slow addition). Isolated yield. Regioselectivty (denoted in parentheses) was calculated by NMR of crude reaction mixture.