Table 2. Subgroup analysis for accuracy of PLA2R-AB for MN detection.
Subgroup | N | Sensitivity | Specificity | DOR | AUC |
Race | |||||
Caucasian | 10 | 0.80(0.62,0.91) | 1.00(0.98,1.00) | 1297 | 0.99(0.97–0.99) |
Asian | 5 | 0.72(0.67,0.77) | 0.91(0.84,0.95) | 26 | 0.91(0.88–0.93) |
Sample size | |||||
<100 subjects | 6 | 0.82(0.66,0.91) | 0.97(0.78,1.00) | 147 | 0.94(0.92–0.96) |
> = 100 subjects | 9 | 0.76(0.59,0.88) | 0.99(0.97,1.00) | 465 | 0.97(0.96–0.99) |
Control | |||||
Patients | 9 | 0.80(0.64,0.90) | 0.98(0.89,1.00) | 220 | 0.95(0.93–0.97) |
Health | 6 | 0.75(0.55,0.88) | 1.00(0.98,1.00) | 914 | 1.00(0.99–1.00) |
Method | |||||
Western blotting | 9 | 0.68(0.62,0.73) | 0.97(0.93,0.99) | 73 | 0.84(0.80–0.87) |
Imunofluorescence | 4 | 0.74(0.37,0.93) | 0.99(0.78,1.00) | 451 | 0.98(0.96–0.99) |
ELISA | 1 | - | - | - | - |
Test interval | |||||
No | 8 | 0.68(0.62,0.73) | 0.95(0.86,0.98) | 39 | 0.78(0.74–0.81) |
After biopsy test | 7 | 0.86(0.65,0.96) | 1.00(0.98,1.00) | 8710 | 1.00(0.99–1.00) |
Funding by | |||||
Government foundation | 9 | 0.70(0.56,0.81) | 0.99(0.90,1.00) | 177 | 0.89(0.86–0.92) |
Corporation or no funding | 6 | 0.88(0.76,0.95) | 0.99(0.96,1.00) | 843 | 0.99(0.98–1.00) |