Skip to main content
. 2014 Aug 19;9(8):e105588. doi: 10.1371/journal.pone.0105588

Figure 1. Recruitment of Xbp1 mRNA to the ER membrane in mammalian cells.

Figure 1

XBP1unspliced originates translational pausing through its C-terminal region. The hydrophobic regions (HR1 and HR2) in XBP1unspliced target the XBP1 unspliced mRNA/ribosome/nascent chain complex to the ER membrane, giving the opportunity for Ire1 to splice Xbp1 mRNA. Adapted from [31].