Table V.
Phase Transition Parameters For Doxycycline Study
| Phase transition Parameter |
MGD* | Enrolled Treatment Time (weeks) |
Enrolled Post Treatment time (weeks) |
Normal | ||
|---|---|---|---|---|---|---|
| (0) | (4) | (8) | (4) | |||
| Minimum Frequency (cm−1) | 2849.68 ± 0.06 | 2849.8 ± 0.1 | 2849.6 ± 0.1 | 2849.7 ± 0.1 | 2849.6 ± 0.1 | 2849.9 ± 0.1 |
| Maximum Frequency (cm−1) | 2853.48 ± 0.07 | 2853.4 ± 0.1 | 2853.5 ± 0.1 | 2853.3 ± 0.2 | 2853.2 ± 0.2 | 2853.5 ± 0.1 |
| Cooperativity | −8.5 ± 0.4 | −9.0 ± 0.4 | −9.7 ± 0.9 | −9.5 ± 0.8 | −8.0 ± 0.8 | −9.2 ± 0.4 |
| Phase transition Temperature (°C) | 32.2 ± 0.5 | 31.8 ± 0.5 | 32.2 ± 0.8 | 31.3 ± 0.6 | 33.0 ± 0.5 | 28.5 ± 0.5 |
| Enthalpy (Kcal/mol) | 157 ± 7 | 143 ± 11 | 158 ± 27 | 159 ± 17 | 127 ± 4 | 149 ± 7 |
| Entropy (Kcal/mol/degree) | 0.51 ± 0.02 | 0.47 ± 0.04 | 0.52 ± 0.09 | 0.52 ± 0.06 | 0.41 ± 0.01 | 0.50 ± 0.08 |
| Order (%) at 33.4°C | 47 ± 2 | 46 ± 3 | 47 ± 3 | 45 ± 3 | 52.7 ± 0.9 | 36 ± 2 |
| Number of samples | 49 | 8 | 6 | 7 | 1 | 9 |
*
MGD is meibomian gland dysfunction. MGD and normal have been reported.42