Table 1.
Pressures and PbtO2 in mmHg.AoS indicates aortic systolic pressure; AoD, aortic diastolic pressure; RAD, right atrial diastolic pressure; ICP, intracranial pressure; CerePP, cerebral perfusion pressure; PbtO2, brain tissue oxygen tension; ET CO2, end tidal carbon dioxide. Depth 33 (D33) and Depth 51 (D51) refer to depth-guided CPR at 33mm and 51 mm, respectively. CPP-20 refers to CPR directed to attain coronary perfusion pressure >20 mmHg. Data presented as mean (SEM).
| Depth 33 (n=7) | Depth 51 (n=6) | CPP-20 (n=8) | p | |
|---|---|---|---|---|
| Baseline | ||||
| Weight (kg) | 32 (0.5) | 33 (0.2) | 33 (1) | 0.77 |
| CO (L/min) | 3.3 (0.3) | 3.0 (0.3) | 2.8 (0.3) | 0.49 |
| AoS | 113(5) | 99(6) | 99(4) | 0.09 |
| AoD | 81(4) | 71(7) | 73(3) | 0.29 |
| CPP | 68 (5) | 66 (6) | 67 (4) | 0.93 |
| ICP | 16 (1) | 20 (3) | 18 (2) | 0.48 |
| CerePP | 76(4) | 64(8) | 65(6) | 0.34 |
| PbtO2 | 22 (4) | 29 (6) | 17 (7) | 0.43 |
| End of Untreated VF* | ||||
| AoS | 26(1) | 25(3) | 23(1) | 0.37 |
| AoD | 20(1) | 15(3) | 20(1) | 0.22 |
| CPP | 2 (1) | 1 (1) | 2 (1) | 0.74 |
| ICP | 15 (1) | 16 (3) | 16 (1) | 0.80 |
| CerePP | 7(2) | 3(4) | 7(2) | 0.77 |
| PbtO2 | 3 (1) | 15 (5) | 4 (3) | 0.08 |
| PbtO2 (% baseline) | 13(4) | 46 (11) | 22(16) | 0.14 |
| End of Resuscitation Period† | ||||
| AoS | 62(11)‡ | 87(9)§ | 110(5) | <0.01 |
| AoD | 23(3)‖ | 31(6)¶ | 47(5) | <0.01 |
| CPP | 8 (2)** | 19 (6) | 38 (7) | <0.01 |
| ICP | 15 (1) | 21 (5) | 22 (2) | 0.18 |
| CerePP | 21 (4)** | 25(8) †† | 51(6) | <0.01 |
| PbtO2 | 10 (5) | 8 (2) | 20 (8) | 0.23 |
| PbtO2 (% baseline) | 37 (12)§§ | 31 (7)‡‡ | 163(55) | 0.019 |
| ET CO2 | 20(3)¶¶ | 35(5)‖‖ | 29(2) | 0.02 |
*
Last epoch during untreated VF period (minute 6 – 7)
†
Last epoch during protocol resuscitation period CPR (minute 16 – 17)
‡
CPP-20 vs. D33: p<0.01;
‖
CPP-20 vs. D33: p<0.01;
**
CPP-20 vs. D33: p<0.01;
§§
p=0.015;
¶¶
p=0.02.
‖‖
D51 vs. D33: p=0.025.
§
CPP-20 vs. D51: p=0.03;
¶
p=0.052;
††
p=0.024;
‡‡
p=0.018.