Figure 5.

Nicotinic receptor blockade varies across odor sets. A, Behavioral results. Performance as a function of test session for the four treatment groups on two individual odor sets (A_i, odor set 7; A_ii, odor set 9). Each curve represents data obtained from one rat; the four curves in each panel, representing the four drug conditions, were obtained from different rats. The effects of MLA infusion are highly variable, ranging from no noticeable effect (A_i) to complete impairment (A_ii). B, Computational results. Performance on two individual odor sets depicted as change in discrimination between the odors in the pair across test sessions when cortical network is trained with bulbar input in each of the four network configurations. Note that in one odor pair (B_i) performance under nicotinic receptor blockade is similar to that of controls, whereas in a second odor set (B_ii), performance under the same condition is notably impaired.