Figure 2.
Systemic injections of the CRF1 receptor antagonist R121919 decreased frustration stress-induced binge eating in rats with a history of intermittent food restriction. Mean ± SEM palatable food intake (kilocalories per kilogram) during the first 15 min (left) and the total 2 h (right) test session. The rats were injected with R121919 (0, 10, or 20 mg/kg, s.c.) 60 min before the start of the test session and exposed or not exposed to 15 min frustration stress before the test session. *p < 0.05, different from the vehicle condition; n = 6–8 per group. #p < 0.05, different from the other three vehicle groups.