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. 2014 Sep;21(9):478–487. doi: 10.1101/lm.035998.114

Figure 2.

Figure 2.

Inhibition of the proteasome impairs the amnesic effect of the SSZ over the reconsolidation of memory in a CPC protocol. However, proteasome inhibition does not impair memory recall. (A) Experimental protocol. On Day 1, the training session was performed. Three groups of control animals did not receive the danger stimulus (CT) and three groups of trained animals received the danger stimulus (TR). On Day 2, each pair of CT/TR group was injected before re-exposure to the training device. The drugs administered were VEH or SSZ (20 μg/animal) or a cocktail of SSZ and MG132. On Day 3, the testing session was performed. Gray horizontal bars indicate light from below, white horizontal bars indicate light from above, and solid black lines indicate the visual danger stimulus presentation. (B) Testing session. Mean response ± SEM on Day 3 normalized to the VEH-CT group; (*) P < 0.05, n = 30, per group. (C) Experimental protocol. On Day 1 the training was performed as before. On Day 2 the animals were injected with VEH or MG132 10 min before the testing session. (D) Testing session. Mean response ± SEM on Day 2 normalized to the VEH-CT group, (*) P < 0.05, n = 30, per group.