Figure 3.

Proteasome inhibition impairs the amnesic effect of the MK801 and the enhancement of bicuculline in the reconsolidation of the memory. (A) Experimental protocol. On Day 1, the training session was performed. Three groups of control animals did not receive the danger stimulus (CT) and three groups of animals received the danger stimulus (TR). On Day 2, each pair of the CT/TR group was injected before re-exposure to the training device. The drugs administered were VEH or MK801 (10 μg/animal) or a cocktail of MK801 and MG132. On Day 3 the testing session was performed. Gray horizontal bars indicate light from below, white horizontal bars indicate light from above, and solid black lines indicate the visual danger stimulus presentation. (B) Testing session. Mean response ± SEM on Day 3 normalized to the VEH–CT group; (*) P < 0.05, n = 30, per group. (C) Experimental protocol. On Day 1, a weak training session was performed. Three groups of control animals did not received the danger stimulus (CT) and three groups of animals received only four trials (TR). On Day 2, each pair of CT/TR group was injected before re-exposure to the training device. The drugs administered were VEH, BIC (46 μg/animal) or a cocktail of BIC and MG132.On Day 3 the testing session was performed. (D) Testing session. Mean response ± SEM on Day 3 normalized to the VEH-CT group; (*) P < 0.05, n = 30, per group.