Figure 1.

NMDA receptor antagonist disrupted reconsolidation of object recognition memory in the absence of retrieval. Recognition index on sample phase, when rats were exposed to two identical objects (A). Animals infused with vehicle showed preference for the novel object (B), contrary to rats infused in the perirhinal cortex with CNQX (C), which did not show preference for any object on the reactivation trial. (D) veh/veh group showed preference for the novel object when tested. Similarly, CNQX/veh group (E) showed preference for the novel object, revealing that reconsolidation was unimpaired despite retrieval inhibition. (F,G) AP5 disrupted reconsolidation whether or not memory retrieval was blocked. (**) P < 0.01 vs. recognition index = 0.5.