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. 2014 Aug 12;6:83. doi: 10.1186/1758-5996-6-83

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© Sadasivuni et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CNX-013-B2 improves insulin sensitivity and glucose tolerance in ob/ob mice. A- OGTT in ob/ob mice at week 4 of treatment. Circle-Lean, Square-ob/ob and Triangle-CNX-013-B2 (10 mpk, bid). B- glucose AUC (0–180 min), C- Fasting (6 h) insulin, D- fed insulin levels, E- p-JNK in liver, F- p-AKT levels in inguinal adipose. All the values are expressed as Mean ± SEM; one way analysis of variance followed by Dunnett’s post hoc test for representing significance value of the treatment groups. P value significance was represented as (*) <0.05, (**) <0.01 and (***) <0.001 when compared with ob/ob control. (#) <0.05 and (##) <0.01 as compared to ob/⁺.