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. 2014 Aug 12;6:83. doi: 10.1186/1758-5996-6-83

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© Sadasivuni et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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CNX-013-B2 reduces body weight and enhances non-shivering thermogenesis. A- Body weight in DIO mice, B-Absolute adipose depot weight, C- mesenteric adipocyte size, D- Body weight gain in ob/ob mice, E-.Cold temperature tolerance in DIO mice, F- SDH activity in gastrocnemius muscle of DIO mice, G and H-, UCPI expression levels in inguinal and brown adipocyte, I- H&E of adipocytes and J-UCP1 quantification in inguinal adipocytes. All the values are expressed as Mean ± SEM; one way analysis of variance followed by Dunnett’s test for representing significance value of the treatment groups. P value significance was represented as (*) <0.05, (**) <0.01 and (***) <0.001 when compared with DIO control. (#) <0.05, (##), <0.01 and (###) <0.001 as compared to lean or ob/⁺.