Table 2.

In vivo suppression of Plasmodium berghei NK65 in mice by limonoids isolated from Carapa guianensis

Dose (mg/kg/day)	% Parasite inhibition				Average survival time ± SD (day)
	Oral		Subcutaneous		Oral	Subcutaneous
	5th day	7th day	5th day	7th day
6α-acetoxygedunin (3)
100	65.7	46.3	44.2	30.4	24 ± 3	22 ± 4
50	40.2	34.7	34.4	16.8	20 ± 3	21 ± 2
7-deacetoxy-7-oxogedunin (4)
100	40.3	28.9	38.6	21.7	21 ± 3	22 ± 2
50	19.3	0	29.2	0	20 ± 2	21 ± 4
chloroquine diphosphate
5	100	98	99	99	>40	>40
control	0	0	0	0	21 ± 2	21 ± 3